Anemia Research Today is a free monthly online journal that collates and summarizes the latest research about Anemia, including details on symptoms, diagnosis, diet, treatment, causes.

Large granular lymphocyte leukemia (LGL) in a child with hyper IgM syndrome and autoimmune hemolytic anemia.

Kitchen BJ, Boxer LA

Division of Hematology/Oncology, Department of Pediatrics and Communicable Diseases, University of Michigan, Mott Children's Hospital, Ann Arbor, Michigan, USA. nkbrenda@umich.edu

We describe a female with a history of autosomal recessive hyper-IgM (HIGM) syndrome along with a history of autoimmune hemolytic anemia and intermittent lymphadenopathy. She subsequently developed neutropenia, lymphocyostosis and mild thrombocytopenia. Flow cytometry of the peripheral blood revealed the presence of a marked predominance of cytotoxic T lymphocytes, shown to be clonal, with concomitant natural killer (NK) antigen expression. She responded to weekly methotrexate therapy.

Published 26 November 2007 in Pediatr Blood Cancer, 50(1): 142-5.
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