Anemia Research Today is a free monthly online journal that collates and summarizes the latest research about Anemia, including details on symptoms, diagnosis, diet, treatment, causes.

No effect of pyridoxine on the incidence of myelosuppression during prolonged linezolid treatment.

Plachouras D, Giannitsioti E, Athanassia S, Kontopidou F, Papadopoulos A, Kanellakopoulou K, Giamarellou H

Fourth Department of Internal Medicine, Attiko University General Hospital, Haidari, Greece. dplach@med.uoa.gr

Complications of long-term linezolid administration include anemia and thrombocytopenia. A recent report has suggested that pyridoxine may prevent myelosuppression. Pyridoxine was administered to 24 patients with bone infections who were being treated with linezolid. Thrombocytopenia occurred in 11 patients (45.8%), and anemia occurred in 6 (25%). We concluded that treatment wtih pyridoxine is unlikely to benefit patients who have been receiving linezolid for >2 weeks.

Published 9 October 2006 in Clin Infect Dis, 43(9): e89-91.
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