Anemia Research Today is a free monthly online journal that collates and summarizes the latest research about Anemia, including details on symptoms, diagnosis, diet, treatment, causes.

Erythropoietin-resistant anaemia in a predialysis patient with Klinefelter syndrome.

Shimizu Y, Suzukawa K, Hirano Y, Seki M, Hirayama K, Yoh K, Hirayama A, Yamagata K, Nagase S, Nagasawa T, Koyama A

Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba City, Ibaraki, Japan. y-shimz@md.tsukuba.ac.jp

A diabetic predialysis patient who had significantly reduced sensitivity to erythropoietin therapy was admitted to Tsukuba University Hospital. Many factors that might have been the cause of the erythropoietin resistance were examined, and a diagnosis of refractory anaemia was made based on a bone marrow aspiration biopsy. A cytogenetic abnormality (47, XXY) was also detected in the bone marrow biopsy specimen, and hence the patient was also diagnosed with Klinefelter syndrome. It was suspected that the sex chromosome abnormality influenced glucose intolerance, renal insufficiency, and erythropoietin resistance due to myelodysplastic changes in the bone marrow.

Published 9 May 2005 in Nephrology (Carlton), 10(2): 147-50.
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