Anemia Research Today is a free monthly online journal that collates and summarizes the latest research about Anemia, including details on symptoms, diagnosis, diet, treatment, causes.

Effect of tacrolimus in a patient with pure red-cell aplasia.

Yoshida S, Konishi T, Nishizawa T, Yoshida Y

Department of Neurology, Utano National Hospital, Narutaki, Kyoto, Japan.

A 78-year-old woman has suffered from pure red-cell aplasia (PRCA) associated with generalized myasthenia gravis and thymoma. Cyclosporin A (CyA) with corticosteroid increased numbers of erythroid cells in her bone marrow cells but she required monthly blood transfusions. Administration of tacrolimus as a substitution for CyA inhibited progression of anemia without the need for further blood transfusion. No serious side effects were observed. This case demonstrates that tacrolimus is another option of treatment for PRCA in patients who fail to respond to CyA.

Published 2 February 2005 in Clin Lab Haematol, 27(1): 67-9.
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