Anemia Research Today is a free monthly online journal that collates and summarizes the latest research about Anemia, including details on symptoms, diagnosis, diet, treatment, causes.

Acquired hemoglobin H disease in a patient with aplastic anemia evolving into acute myeloid leukemia.

Figueiredo MS, Vicari P, Kimura EY, Antunes SV, Yamamoto M

Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, Brazil. stella@hemato.epm.br

CONTEXT: The prognosis of severe aplastic anemia has improved since the introduction of bone marrow transplantation and treatment with antithymocyte globulin. In contrast to the success of these protocols, studies with long term follow-up have shown the occurrence of clonal diseases such as paroxysmal nocturnal hemoglobinuria, myelodysplastic syndrome and acute leukemia in aplastic anemia. CASE REPORT: We report the first case of a Brazilian patient with aplastic anemia who developed myelodysplastic syndrome and acute myeloid leukemia showing acquired hemoglobin H and increased fetal hemoglobin.

Published 4 February 2005 in Sao Paulo Med J, 122(6): 273-5.
Full-text of this article is available online (may require subscription).

© 2004-2008 Anemia Research Today. All Rights Reserved.