Anemia Research Today is a free monthly online journal that collates and summarizes the latest research about Anemia, including details on symptoms, diagnosis, diet, treatment, causes.

Thrombotic microangiopathy after combined autografting-allografting for multiple myeloma - report of three cases.

Kornacker M, Luft T, Ho AD, Schaefer HJ

Department of Medicine V, University of Heidelberg, Heidelberg, Germany. martin_kornacker@med.uni-heidelberg.de

Thrombotic microangiopathy (TMA) has been described as a complication of bone marrow or stem cell transplantation. It is usually associated with high dose therapy for autologous transplantation or myeloablative conditioning in the allogeneic setting. Here we report three cases of TMA after reduced intensity conditioning and allogeneic peripheral blood stem cell transplantation. All three patients had high dose Melphalan therapy with autologous stem cell support preceding the allogeneic transplantation for several weeks, which may have contributed to endothelial damage and subsequent development of TMA.

Published 7 February 2005 in Eur J Haematol, 74(3): 250-3.
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