Anemia Research Today is a free monthly online journal that collates and summarizes the latest research about Anemia, including details on symptoms, diagnosis, diet, treatment, causes.

Prolonged course of pure red cell aplasia after erythropoietin therapy.

Nigg L, Schanz U, Ambühl PM, Fehr J, Bachli EB

Renal Division, Department of Medicine, University Hospital, Zurich, Switzerland.

Pure red cell aplasia (PRCA) caused by neutralising anti-erythropoietin antibodies is a very rare disease. Since 1998, an increased incidence of PRCA in patients with kidney failure following treatment with recombinant human erythropoietin (rhEpo) has been reported, mostly in Europe. In most cases, PRCA was cured by immunosuppressive therapy, immunoglobulins, plasmapheresis or renal transplantation. We report an exceptionally prolonged course of PRCA over 68 months despite renal transplantation and different immunosuppressive regimens.

Published 1 October 2004 in Eur J Haematol, 73(5): 376-9.
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